Synthesis of functionalized 4-phenyl-pyridines via electrochemically prepared organozinc reagents

Authors
Le Gall, E Gosmini, C Nedelec, JY Perichon, J
Citation
E. Le Gall et al., Synthesis of functionalized 4-phenyl-pyridines via electrochemically prepared organozinc reagents, TETRAHEDRON, 57(10), 2001, pp. 1923-1927
Citations number
28
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON
ISSN journal
00404020 → ACNP
Volume
57
Issue
10
Year of publication
2001
Pages
1923 - 1927
Database
ISI
SICI code
0040-4020(20010303)57:10<1923:SOF4VE>2.0.ZU;2-X
Abstract
The efficient and convenient synthesis of various functionalized 4-phenyl-p yridines 2 is described. The key step of the procedure is the electrochemic al formation of aromatic organozinc reagents 1 and their coupling with pyri dinium salts, intermediate 1,4-dihydro-pyridines are oxidized using mild co nditions to provide functionalized 4-phenyl-pyridines in moderate to high o verall yields. (C) 2001 Elsevier Science Ltd. All rights reserved.