Synthesis of 5-alkyl-4-amino-2-(trifluoromethyl)pyridines and their transformation into trifluoromethylated 1H-pyrazolo[4,3-c]pyridines

Authors
Tyvorskii, VI Bobrov, DN Kulinkovich, OG Tehrani, KA De Kimpe, N
Citation
Vi. Tyvorskii et al., Synthesis of 5-alkyl-4-amino-2-(trifluoromethyl)pyridines and their transformation into trifluoromethylated 1H-pyrazolo[4,3-c]pyridines, TETRAHEDRON, 57(10), 2001, pp. 2051-2055
Citations number
17
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON
ISSN journal
00404020 → ACNP
Volume
57
Issue
10
Year of publication
2001
Pages
2051 - 2055
Database
ISI
SICI code
0040-4020(20010303)57:10<2051:SO5ATT>2.0.ZU;2-I
Abstract
5-Alkyl-4-amino-2-(trifluoromethyl)pyridines were prepared in good yields s tarting from the corresponding pyridinols either using condensation with to syl isocyanate or by alkylation with 2-chloroacetamide and subsequent Smile s type rearrangement. The cyclisation of diazonium salts, generated from 5- alkyl-4-amino-2-(trifluoromethyl)pyridines afforded trifluoromethylated 1H- pyrazolo[4,3-c] pyri dines. (C) 2001 Elsevier Science Ltd. All rights reser ved.