Background and Purpose: The purpose of this study was to examine the associ
ation between hemostatic activation and stroke severity, and to provide dat
a on hemostatic variables in acute ischemic stroke. Methods: The patient ma
terial comprised 76 consecutive patients with acute ischemic stroke (median
16 h, interquartile range 3-48). Levels of hemostatic variables were deter
mined in blood samples collected on the day of hospitalization. Stroke seve
rity was assessed on admission by the Oxfordshire Community Stroke Project
(OCSP) classification, and on discharge (median 9 days, interquartile range
6-14) by Barthel Index (BI, scores 0-50, 55-90, or 95-100) and modified Ra
nkin Scale (mRS, scores 0-1 or 2-6). Associations were assessed by multiple
linear regression analyses. Results: Levels of the fibrin degradation prod
uct D-Dimer and the activation peptide prothrombin fragment 1+2 (F1+2) were
linearly related to stroke severity, whether assessed on admission (P=.001
and .03, respectively, for the OCSP classification), or on discharge (P=.0
09 and .43, respectively, for BI; and .001 and .05, respectively, for mRS).
High levels of D-Dimer and F1+2, as well as low levels of antithrombin and
protein C were also present in patients with a presumed embolic source, an
d low antithrombin or protein C was borderline significantly associated wit
h atrial fibrillation (P=.072 and .058, respectively). Low levels of protei
n C or protein S, and the presence of antiphospholipid antibodies, includin
g lupus anticoagulant (LA), was detected in 13/73 (18%) and 15/70 (21%) of
the patients, respectively. Conclusion: Activation of the hemostatic system
is independently related to acute stroke severity and short-term outcome.
Low levels of coagulation inhibitors or presence of antiphospholipid antibo
dies is a relatively frequent finding in unselected patients with acute isc
hemic stroke, but a causative role cannot be inferred from our study. (C) 2
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