THE UTILIZATION OF A BIOLOGICAL ADHESIVE FOR WOUND TREATMENT - COMPARISON OF SUTURE, SELF-SEALING SUTURELESS AND CYANOACRYLATE CLOSURE IN THE TENSILE-STRENGTH TEST

We produced a measurement apparatus for testing the tensile strength o f wounds during cataract surgery, and tested the tensile strength of t reated wounds including wounds sutured with various methods, non-sutur ed and wounds treated with various bio-tissue adhesives. Methods. In c ataract surgery on white rabbits eyes, a corneoscleral incision 5 mm i n length was made 2.5 mm from the limbus corneae, and entry into the a nterior chamber was obtained 0.5 mm to the clear cornea. After treatme nt for closure, the corneoscleral piece was subjected to the tensile s trength test. Results. The tensile strengths just after surgery were ( 1) 0 gf/mm(2) after self-sealing sutureless closure; (2) 114 gf/mm(2) after vertical suture closure (one stitch with 10-0 nylon); (3) 125 gf /mm(2) after horizontal suture closure (one stitch with 10-0 nylon); ( 4) 143 gf/mm(2) after infinity suture closure (with 10-0 nylon); (5) 1 12 gf/mm(2) after fibrin glue (Beriplast(R)P) application (instilled o n the surface of scleral incision); (6) 121 gf/mm(2) after fibrin glue application (glued on corneoscleral wound); (7) 131 gf/mm(2) after cy anoacrylate closure (instilled on the surface of scleral incision); (8 ) 139 gf/mm(2) after cyanoacrylate closure (glued on corneoscleral wou nd). The respective strengths at four days after surgery were: (1) 86; (2) 131; (3) 137; (4) 175; (5) 109; (6) 43; (7) 138; and (8) 108 gf/m m(2). At 28 days after surgery, the respective strengths were (1) 164; (2) 167; (3) 184; (4) 209; (5) 322; (6) 195; (7) 251; and (8) 175 gf/ mm(2). Conclusion. The use of fibrin glue in treatment of a wound in c ataract surgery is beneficial in assisting this treatment.