FORCE, DEVELOPMENT, AND NEOPLASIA - DEVELOPMENT FROM ANOTHER PERSPECTIVE AS ILLUSTRATED THROUGH A STUDY OF IN-VITRO PLANT DEVELOPMENT FROM NEOPLASM

Differentiation from the neoplastic state can be a dynamic adaptation to the localized stress of increasing cohesive forces in tissue. Repul sive forces, occurring within and between cells, are seen as leading t o de-differentiation into the neoplastic State or neoplasm. During ear ly development, especially where and when mitosis occurs frequently, c ohesive and repulsive forces may necessarily coexist in oscillating de grees. Correspondingly, cohesive-force and repulsive-force generating metabolites may co-exist in oscillating concentrations. Cancer or neop lasia occurs, according A. Szent-Gyorgyi, when cohesiveness breaks dow n locally, probably thru the conversion of methylglyoxal into lactic a cid. Cancer may also occur due to the accumulation of such putatively, repulsion-generating factors as lactic acid Plant tumors in vitro res pond adaptively to cohesion-generating chemicals, such as ascorbic aci d and methylglyoxal, by generating buds, embryos, and plantlets.