A phospholipase C inhibitor, phenylmethylsulfonyl fluoride, ameliorates ischemic injury to brain mitochondria in rats

Authors
Wang, QS Zhou, JN Xu, TL Li, LS
Citation
Qs. Wang et al., A phospholipase C inhibitor, phenylmethylsulfonyl fluoride, ameliorates ischemic injury to brain mitochondria in rats, ACT PHAR SI, 22(3), 2001, pp. 249-252
Citations number
11
Categorie Soggetti
Pharmacology & Toxicology
Journal title
ACTA PHARMACOLOGICA SINICA
ISSN journal
02539756 → ACNP
Volume
22
Issue
3
Year of publication
2001
Pages
249 - 252
Database
ISI
SICI code
0253-9756(200103)22:3<249:APCIPF>2.0.ZU;2-H
Abstract
AIM: To study the effect of phenylmethylsulfonyl fluoride (PMSF), a phospho lipase C inhibitor, on ischemic injury to brain mitochondria in rats. METHO DS: The phospholipid level, membrane fluidity, and respiratory control rati o of brain mitochondria were measured. The effect of phenylmethylsulfonyl f luoride was tested. RESULTS: The phospholipid level, membrane fluidity, and respiratory control ratio of brain mitochondria in ischemia group decrease d but increased in the PMSF treatment group(P < 0.05). CONCLUSION: PMSF ame liorated ischemic injury to brain mitochondria in rats.