THE HUMAN IN-VIVO ANTIMICROBIAL EFFECTS OF DUAL ACNE THERAPY - ORAL DYNACIN(R) (MINOCYCLINE HCL) PLUS TOPICAL TRIAZ(R) (BENZOYL PEROXIDE SPECIAL GEL)

In two recent, separate in vivo antimicrobial studies, orally administ ered Dynacin(R) (minocycline HCl) produced superior reduction of Propi onibacterium acnes compared with doxycycline and tetracycline, and top ically applied Triaz(R) (benzoyl peroxide special gel) produced compar ably superior reduction in P. acnes compared with clindamycin phosphat e lotion and azelaic acid cream. These findings stimulated interest in evaluating the in vivo antimicrobial efficacy of the combination of D ynacin :LOG mg twice daily orally, and topical Triaz 10% gel twice dai ly, each used daily for 6 weeks, with measurement of the residual anti microbial effect 3 weeks post-dosage. After 3 weeks of treatment, ther e was a substantial, 2.5 log reduction in P. acnes from a baseline log count of 6.21 (1 112 000 organisms) to 3.52 (3311 organisms). After 6 weeks on this combination therapy, the reduction in P. acnes was dram atic; a count of log 2.24 or only 173 organisms was found. All reducti ons were statistically significant compared with baseline (P=<0.01). A t 3 weeks after therapy had ceased, the level of P. acnes was still re duced significantly (P=<0.01) compared with baseline.