Effect of pravastatin on plasma markers of inflammation and peripheral endothelial function in male heart transplant recipients

Authors
Holm, T Andreassen, AK Ueland, T Kjekshus, J Froland, SS Kjekshus, E Simonsen, S Aukrust, P Gullestad, L
Citation
T. Holm et al., Effect of pravastatin on plasma markers of inflammation and peripheral endothelial function in male heart transplant recipients, AM J CARD, 87(6), 2001, pp. 815
Citations number
12
Categorie Soggetti
Cardiovascular & Respiratory Systems","Cardiovascular & Hematology Research
Journal title
AMERICAN JOURNAL OF CARDIOLOGY
ISSN journal
00029149 → ACNP
Volume
87
Issue
6
Year of publication
2001
Database
ISI
SICI code
0002-9149(20010315)87:6<815:EOPOPM>2.0.ZU;2-N
Abstract
Statins appear to have several biologic effects beyond those of lipid metab olism, and we hypothesized that immunomodulating effects of statins are imp ortant for the beneficial effects of these medications after heart transpla ntation. Our findings suggest that pravastatin treatment reduces plasma mar kers of inflammation and improves peripheral endothelial function in heart transplant recipients, possibly contributing to the observed clinical benef its of statin treatment in these patients.