RI in central retinal artery as assessed by CDI does not correspond to retinal vascular resistance

The aim of the present study was to investigate the association between ult rasound Doppler measurements of resistive index (RI) in the central retinal artery and retinal vascular resistance (R) assessed with laser Doppler vel ocimetry, vessel size measurement, and calculation of ocular perfusion pres sure (PP) in healthy subjects. An increase in vascular resistance was induc ed by inhalation of 100% O-2. During hyperoxia no significant changes in PP were observed. Mean flow velocity in main retinal veins was reduced by -27 .5 +/- 2.0%. The average decrease in diameter was -11.5 +/- 1.0%. R, which was calculated as the ratio of PP to flow rate, increased by 97.6 +/- 7.7%. RI increased as well, but the effect was much smaller (6.6 +/- 2.2%). In a ddition, a negative correlation was found between baseline values of R and RI (r = -0.83). During hyperoxia R and RI were not associated. In conclusio n, our data indicate that RI as assessed with color Doppler imaging in the central retinal artery is not an adequate measure of R.