Sixteen patients were treated for sternal wound infections after undergoing
cardiac procedures. Their management involved prompt surgical debridement
and quantitative wound biopsies. At the time of the initial debridement, th
e Vacuum-Assisted Closure Device (V.A.C.) was placed in the open sternal wo
und. A subatmospheric environment was maintained by the device at a level o
f 75 to 150 mmHg, The V.A.C, sponge was changed every 2 to 3 days, and oper
ative debridement was performed until quantitative biopsies showed resoluti
on of infection or until systemic signs of sepsis had resolved. At this tim
e the sternal wounds were closed with regional muscle flaps. Patients were
excluded from the use of the device if the pleural cavity was entered durin
g operative debridement. Fifteen of the 16 patients survived and went on to
complete wound healing and discharge from the hospital (average length of
stay, 16.7 days). One patient sustained a cardiac dysrhythmia during the mu
scle flap procedure and died, There were no complications related directly
to the use of the V.A.C. It is the opinion of the authors that the V.A.C. o
ffers several advantages over their traditional methods of treatment. They
noted improvement in sternal wound stabilization during the perioperative p
eriod and a decreased need for paralysis and mechanical ventilation. Wound
management was improved by avoiding the need to perform debridement or to m
ake desiccating dressing changes to an open sternum. Moreover, they also th
ink that this device may lessen the risk for ventricular rupture because of
better control of the wound environment and markedly improved stabilizatio
n of the debrided sternal elements.