Resection of adrenal metastases from non-small cell lung cancer: A multicenter study

Background. In recent case reports and limited series, adrenalectomy was re commended for an isolated adrenal metastasis from non-small cell lung cance r (NSCLC). Methods. We retrospectively studied patients with a solitary adrenal metast asis from NSCLC who had undergone potentially curative resection in eight c enters. Results. Forty-three patients were included. Their adrenal gland metastasis was discovered synchronously with NSCLC in 32 patients, and metachronously in 11. It was homolateral to the NSCLC in 31 patients and contralateral in 12 (p < 0.01). Median survival was 11 months, and 3 patients survived more than 5 years. There was no difference between the synchronous and metachro nous groups regarding recurrence rate or survival. Survival was not affecte d by the homolateral location of the metastasis, the histology of the NSCLC , TNM stage, any adjuvant and neoadjuvant treatment, or, in the metachronou s group, a disease-free interval exceeding 6 months. Conclusions. We confirm the possibility of long-term survival after resecti on of isolated adrenal metastasis from NSCLC, but no clinical or pathologic criteria were detected to identify patients amenable to potential cure. (C ) 2001 by The Society of Thoracic Surgeons.