Psychosocial factors appear to impact upon the development and progression
of such chronic diseases as coronary heart disease, cancer, and HIV/AIDS. S
imilarly, psychosocial interventions have been shown to improve the quality
of life of patients with established disease and seem to influence biologi
cal processes thought to ameliorate disease progression. Small-scale studie
s are useful for specifying the conditions under which psychosocial factors
may or may not impact quality of Life, biological factors, and disease pro
gression. They are also useful for informing us about the conditions under
which psychosocial interventions can serve as adjuvants (e.g. adherence tra
ining) to medical treatments. Only large-scale clinical trials, however, ca
n determine the extent to which these psychosocial interventions may impact
morbidity and mortality.