Synthesis and biological activity of the structural analogues of (-)-cabenegrin A-I

Authors
Gulacsi, K Litkei, G Antus, S Szantay, C Darko, LL Szelenyi, J Hasko, G Vizi, SE
Citation
K. Gulacsi et al., Synthesis and biological activity of the structural analogues of (-)-cabenegrin A-I, ARCH PHARM, 334(2), 2001, pp. 53-61
Citations number
23
Categorie Soggetti
Pharmacology & Toxicology
Journal title
ARCHIV DER PHARMAZIE
ISSN journal
03656233 → ACNP
Volume
334
Issue
2
Year of publication
2001
Pages
53 - 61
Database
ISI
SICI code
0365-6233(200102)334:2<53:SABAOT>2.0.ZU;2-Q
Abstract
A series of phenylbutene and butanol derivatives (6a-j, 12, 13, 15, 17, 24b ,c, 26, 27a,b) were prepared from the readily available resorcinol derivati ves 2a-f and 7-hydroxy-chroman (18). The products were tested for inhibitor y activity on the LPS-induced TNF-alpha production in the plasma in compari son with that of cabenegrin A-I (1a).