Primary paratesticular lymphoma - A report of 2 cases and review of the literature

Non-Hodgkin lymphoma arising in the paratesticular organs without testicula r involvement is rare. In most previously reported cases, the classificatio n systems that were used are now outdated and/or immunologic studies were n ot done. We report the clinical and pathologic features of 2 cases of non-H odgkin lymphoma arising in the epididymis and the spermatic cord. Patient 1 was a 35-year-old man who presented with a painless scrotal mass. Patient 2 was a 61-year-old man who presented with a right inguinal mass. Orchiecto my performed in both patients revealed a mass confined to the epididymis in patient 1 and to the spermatic cord in patient 2. Histologic examination i n both cases revealed diffuse large cell lymphoma, and immunohistochemical studies supported B-cell lineage. Subsequent staging studies showed no othe r site of disease in patient 1 and an isolated mass anterior to the right p soas muscle in patient 2. Malignant lymphoma involving testicular adnexal s tructures without involvement of the testis is extremely uncommon. To our k nowledge, only 6 cases confined to the epididymis and 12 cases confined to the spermatic cord have been reported previously.