Role of IL-12 in Staphylococcus aureus-triggered arthritis and sepsis

Authors
Hultgren, OH Stenson, M Tarkowski, A
Citation
Oh. Hultgren et al., Role of IL-12 in Staphylococcus aureus-triggered arthritis and sepsis, ARTHRITIS R, 3(1), 2001, pp. 41-47
Citations number
48
Categorie Soggetti
Rheumatology
Journal title
ARTHRITIS RESEARCH
ISSN journal
14659913 → ACNP
Volume
3
Issue
1
Year of publication
2001
Pages
41 - 47
Database
ISI
SICI code
1465-9913(2001)3:1<41:ROIISA>2.0.ZU;2-M
Abstract
The present study demonstrates that endogenous production of IL-12 is cruci al for survival in Staphylococcus aureus-induced arthritis in mice. Staphyl ococcal load is enhanced in several organs, because of lack of IL-12. This might be due to decreased production of IFN-gamma in IL-12-deficient mice. Although IL-12-deficient mice were exposed to higher staphylococcal load, t hey demonstrated no increased severity of arthritis as compared with contro l animals.