Bone loss occurs when the cellular events of bone formation are quantitativ
ely larger than bone formation. This manuscript discusses the measurement o
f bone loss, occurrence in the population, risk factors and consequences of
bone loss. Recent developments in bone mass measurement and biomarkers hav
e improved our ability to assess bone loss. This process is a normal concom
itant of ageing. There are a number of other risk factors, including sex ho
rmone deficiency, physical inactivity, calcium/vitamin D deficiency, inflam
matory arthritis, corticosteroids, smoking and alcohol. The major consequen
ce of bone loss in our ageing society is fracture.