Cytokine, activation marker, and chemokine receptor expression by individual CD4(+) memory T cells in rheumatoid arthritis synovium

Authors
Nanki, T Lipsky, PE
Citation
T. Nanki et Pe. Lipsky, Cytokine, activation marker, and chemokine receptor expression by individual CD4(+) memory T cells in rheumatoid arthritis synovium, ARTHRITIS R, 2(5), 2000, pp. 415-423
Citations number
27
Categorie Soggetti
Rheumatology
Journal title
ARTHRITIS RESEARCH
ISSN journal
14659913 → ACNP
Volume
2
Issue
5
Year of publication
2000
Pages
415 - 423
Database
ISI
SICI code
1465-9913(2000)2:5<415:CAMACR>2.0.ZU;2-1
Abstract
IL-10, IL-13, IFN-gamma, tumor necrosis factor (TNF)-alpha, LT-alpha, CD154 , and TNF-related activation-induced cytokine (TRANCE) were expressed by 2- 20% of rheumatoid arthritis (RA) synovial tissue CD4(+) memory T cells, whe reas CD4(+) cells that produced IL-2, IL-4, or IL-6 were not detected. Expr ession of none of these molecules by individual CD4+ cells correlated with the exception of TRANCE and IL-10, and TRANCE and TNF-alpha. A correlation between expression of IL-10 and CCR7, LT-alpha and CCR6, IFN-gamma and CCR5 , and TRANCE and CXCR4 was also detected.