3-anilino-4-arylmaleimides: Potent and selective inhibitors of glycogen synthase kinase-3 (GSK-3)

Authors
Smith, DG Buffet, M Fenwick, AE Haigh, D Ife, RJ Saunders, M Slingsby, BP Stacey, R Ward, RW
Citation
Dg. Smith et al., 3-anilino-4-arylmaleimides: Potent and selective inhibitors of glycogen synthase kinase-3 (GSK-3), BIOORG MED, 11(5), 2001, pp. 635-639
Citations number
36
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
11
Issue
5
Year of publication
2001
Pages
635 - 639
Database
ISI
SICI code
0960-894X(20010312)11:5<635:3PASIO>2.0.ZU;2-C
Abstract
Potent 3-anilino-4-arylmaleimide glycogen synthase kinase-3 (GSK-3) inhibit ors have been prepared using automated array methodology. A number of these are highly selective, having little inhibitory potency against more than 2 0 other protein kinases. (C) 2001 Elsevier Science Ltd. All rights reserved .