RPR203494 a pyrimidine analogue of the p38 inhibitor RPR200765A with an improved in vitro potency

Authors
Collis, AJ Foster, ML Halley, F Maslen, C McLay, IM Page, KM Redford, EJ Souness, JE Wilsher, NE
Citation
Aj. Collis et al., RPR203494 a pyrimidine analogue of the p38 inhibitor RPR200765A with an improved in vitro potency, BIOORG MED, 11(5), 2001, pp. 693-696
Citations number
9
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
11
Issue
5
Year of publication
2001
Pages
693 - 696
Database
ISI
SICI code
0960-894X(20010312)11:5<693:RAPAOT>2.0.ZU;2-Z
Abstract
Following the discovery of RPR200765, a series of pyrimidine analogues have been prepared as backups. Amongst them, RPR203494 was identified with a be tter in vitro profile than RPR200765A. (C) 2001 Elsevier Science Ltd. All r ights reserved.