Design of non-peptide CCK2 and NK1 peptidomimetics using 1-(2-nitrophenyl)thiosemicarbazide as a novel common scaffold

Authors
Dziadulewicz, EK Walpole, CS Snell, CR Wrigglesworth, R Hughes, GA Beattie, D Wood, JN Beech, MM Coote, PR
Citation
Ek. Dziadulewicz et al., Design of non-peptide CCK2 and NK1 peptidomimetics using 1-(2-nitrophenyl)thiosemicarbazide as a novel common scaffold, BIOORG MED, 11(5), 2001, pp. 705-709
Citations number
22
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
11
Issue
5
Year of publication
2001
Pages
705 - 709
Database
ISI
SICI code
0960-894X(20010312)11:5<705:DONCAN>2.0.ZU;2-M
Abstract
A beta -turn overlay hypothesis has been used to transform the core scaffol d of a selective non-peptide bradykinin B-2 receptor antagonist into ligand s specifically recognized by the CCK2 or NK1 receptors. (C) 2001 Elsevier S cience Ltd. All rights reserved.