The design of phenylglycine containing benzamidine carboxamides as potent and selective inhibitors of factor Xa

Authors
Jones, SD Liebeschuetz, JW Morgan, PJ Murray, CW Rimmer, AD Roscoe, JME Waszkowycz, B Welsh, PM Wylie, WA Young, SC Martin, H Mahler, J Brady, L Wilkinson, K
Citation
Sd. Jones et al., The design of phenylglycine containing benzamidine carboxamides as potent and selective inhibitors of factor Xa, BIOORG MED, 11(5), 2001, pp. 733-736
Citations number
9
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
11
Issue
5
Year of publication
2001
Pages
733 - 736
Database
ISI
SICI code
0960-894X(20010312)11:5<733:TDOPCB>2.0.ZU;2-Q
Abstract
Factor Xa, a critical serine protease in the blood coagulation cascade, has become a target for inhibition as a strategy for the invention of novel an ti-thrombotic agents. Here we describe the development of phenylglycine con taining benzamidine carboxamides as novel, potent and selective inhibitors of factor Xa. (C) 2001 Elsevier Science Ltd. All rights reserved.