Structure-activity relationship on the human EP3 prostanoid receptor by use of solid-support chemistry

Authors
Juteau, H Gareau, Y Labelle, M Lamontagne, S Tremblay, N Carriere, MC Sawyer, N Denis, D Metters, KM
Citation
H. Juteau et al., Structure-activity relationship on the human EP3 prostanoid receptor by use of solid-support chemistry, BIOORG MED, 11(5), 2001, pp. 747-749
Citations number
24
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
11
Issue
5
Year of publication
2001
Pages
747 - 749
Database
ISI
SICI code
0960-894X(20010312)11:5<747:SROTHE>2.0.ZU;2-Q
Abstract
Potent and selective EP3 receptor ligands were found by making a library us ing solid-support chemistry. These compounds can be obtained by a Suzuki co upling reaction of a solid-supported benzyl bromide using various boronic a cids. The yields obtained for this reaction were in the range of 24-95% of arylmethyl cinnamic acid 1 after cleavage from the Wang resin. (C) 2001 Pub lished by Elsevier Science Ltd.