The influence of external environment fluctuations on the signal formationof microbiosensors

This part of theoretical analysis describes the fluctuations of output sign al of microbiosensors when the number of accessible molecular recognition e lements (enzymes, receptors, antibodies, etc.) fluctuated under external en vironmental influences. The mean electric current, dispersion correlating f unction, as well as spectral density of output current fluctuation are anal yzed, and it is shown that a comparison of theoretically calculated mean cu rrent and correlation function with experimental data allow a determination of the kinetic parameters of substrate binding reaction with the molecular recognition element of biosensor. (C) 2001 Published by Elsevier Science B .V.