P53 MUTATIONS OF LUNG-CANCER ARE NOT SIGNIFICANTLY AFFECTED BY CYP1A1OR GSTM1 POLYMORPHISMS

Cytochrome p4501A1 gene (CYP1A1) and glutathione S-transferase mu gene (GSTM1) are involved in the metabolic activation or detoxification of environmental carcinogens including benzo[a]pyrene in tobacco smoke. Individuals with both Val/Val and C type of CYP1A1 (CYP1A1; Val/Val an d CYP1A1; C) or homozygous null (-/-) genotype of GSTM1 gene (GSTM1; - /-) show increased susceptibility to lung cancer. The incidence of p53 gene mutations are related to the smoking index of the lung cancer pa tients. Therefore we determined genotypes of these enzymes and screene d p53 gene mutations in 123 non-small cell lung cancer (NSCLC) patient s. p53 gene mutations were found in 35% (43/123) of the patients. The incidence of p53 gene mutation CYP1A1; Val/Val (60.0%), CYP1A1; C (50. 0%) tended to be higher than those of CYPIAI; Ile/Ile and Ile/Val (40. 4%) or CYP1A1; A and B (40.5%). We conclude that the incidence of the p53 mutations does not seem to be significantly affected by only CYP1A 1 or GSTM1 polymorphisms in lung cancer patients.