IN-VITRO AND IN-VIVO MRS STUDY OF HUMAN GLIOMA METABOLITES

In this study an in vitro multinuclear magnetic resonance spectroscopy (MRS) characterization of water soluble metabolites and of the lipid fraction obtained from 19 human gliomas (12 glioblastomas, 3 anaplasti c astrocytomas, 2 anaplastic oligodendrogliomas and 2 oligodendrogliom as) with a total of 27 surgical specimens, is reported. Moreover, some in vivo H-1 MRS results are shown. The regional metabolic heterogenei ty of glioblastomas, according to their morphological heterogeneity, i s documented. For glioblastomas a specific in vitro H-1 MRS metabolite profile cannot be defined. Low and high grade oligodendrogliomas show ed characteristic choline/creatine and alanine/creatine metabolite rat ios. The spectroscopical characterization of histopathological factors concerning malignant gliomas is shown.