A recently recognised chronic inflammatory disease of early onset characterised by the triad of rash, central nervous system involvement and arthropathy

Chronic Infantile Neurological Cutaneous and Articular (CINCA) syndrome, al so called Neonatal Onset Multisystemic Inflammatory Disease (NOMID) is char acterised by the triad of cutaneous rash, chronic meningitis and arthropath y. It is a chronic inflammatory illness that star ts most often at birth an d persists for the whole lifespan of the patient. Attempts at therapy have been disappointing. The long-term prognosis is poor, with progressive deafn ess and visual impairment, and worsening of the central nervous system mani festations. Some cases of death have been reported secondary to infection, vasculitis and amyloidosis. Usually observed as sporadic cases, some famili al association is recognised.