The low-birth weight infant with critical congenital heart defects is likel
y to be at a higher risk for postoperative death and complications than the
ir normal-sized counterparts. The causes of this increased mortality and mo
rbidity are multifactorial: technical issues related to small cardiac struc
tures and cannulation for cardiopulmonary bypass, immaturity of other organ
systems, decreased nutritional and cardiac reserve, increased risks of ble
eding from bypass-related coagulopathy; and abnormal chest wall mechanics a
fter median sternotomy. Current experience, however, does not support the p
ractice of waiting to obtain an arbitrary weight before surgery in the hope
s of improving outcome. A multidisciplinary approach is required to achieve
optimal results.