Ho. Ventura et K. Muhammed, Historical perspectives on cardiac transplantation: the past as prologue to challenges for the 21st century, CURR OPIN C, 16(2), 2001, pp. 118-123
The development of cardiac transplantation is based on experimental studies
that started in the beginning of the last century. The improvement in the
surgical technique for cardiac transplantation, associated with other progr
ess in the field of cardiac surgery and a better understanding of the immun
e responses, allowed cardiac transplantation to become a reality for the tr
eatment of endstage heart disease. Recent development in immunosuppressive
agents and advances in cardiac surgery have meant that cardiac transplantat
ion is not a "fantastic speculation for the future," but a reality for the
present. Thus, cardiac transplantation is performed around the world with a
n excellent survival rate and has become a lifesaving treatment for many pa
tients with severe heart disease. Curr Opin Cardiol 2001, 16:118- 123 (C) 2
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