MULTIFOCAL EOSINOPHILIC GRANULOMA WITH SEQUENTIAL PERIODONTITIS-LIKE LESIONS (CORRECTED VERSION OF XE471)

Eosinophilic granuloma (EG) is the localized and mildest form of the t riad commonly known as Langerhans cell histiocytosis. This report desc ribes a case manifesting itself as a periodontal problem with the loca lized osseous lesions in jawbones which was first diagnosed as early-o nset periodontitis. Later on, the diagnosis of EG was established, rel ying on histopathological and immunohistochemical evaluations. Immunoh istochemical findings confirm that a minor component of cell aggregate s is phenotypically related to Langerhans cells among the sheet-like a ccumulations of histiocytes and eosinophils. The aetiology of the dise ase remains largely unknown. Although surgical curettage of lesions is usually effective in treatment of EG of bone, corticosteroids might b e used as an adjunctive. This multifocal case of EG stresses the impor tance of clinical follow-up examinations, since the sequential lesions appear with irregular intervals, and this may cause diagnostic proble ms as well as a delay in starting the treatment regimen.