Lipoprotein lipase: Physiology, biochemistry, and molecular biology

Lipoprotein lipase (LpL) is the primary enzyme responsible for conversion o f lipoprotein triglyceride into free fatty acids and monoglyderides. This p ermits their uptake into muscle and adipose. The roles of this enzyme in no rmal and altered physiology are reviewed. In addition, the relationship of LpL activity and genetic variations of LpL and human disease are summarized .Lipoprotein lipase (LpL) is the primary enzyme responsible for conversion of lipoprotein triglyceride into free fatty acids and monoglyderides. This permits their uptake into muscle and adipose. The roles of this enzyme in n ormal and altered physiology are reviewed. In addition, the relationship of LpL activity and genetic variations of LpL and human disease are summarize d.