Members of the low density lipoprotein receptor family control diverse physiological processes

The low density lipoprotein receptor (LDLR) family is a group of receptors that mediate endocytosis leading to lysosomal degradation of an enormous re pertoire of ligands. To date, over 50 distinct macromolecules have been sho wn to bind members of the family. This wide spectrum of ligand recognition is the basis for an immense diversity in physiological processes in which t hese receptors participate. In this article, the physiological roles of the LDLR family members are briefly reviewed and a comprehensive list of the l igands with which the receptors interact is presented.The low density lipop rotein receptor (LDLR) family is a group of receptors that mediate endocyto sis leading to lysosomal degradation of an enormous repertoire of ligands. To date, over 50 distinct macromolecules have been shown to bind members of the family. This wide spectrum of ligand recognition is the basis for an i mmense diversity in physiological processes in which these receptors partic ipate. In this article, the physiological roles of the LDLR family members are briefly reviewed and a comprehensive list of the ligands with which the receptors interact is presented.