Communication issues in 22q11.2 deletion syndrome: Children at risk

Purpose: The purpose of this investigation is to describe the communication profile of children with the 22q11.2 deletion syndrome from infancy throug h school age and to examine the influence of other medical aspects, such as palate anomalies. learning disorders, and cardiac defects of the syndrome to communication. Methods: Seventy-nine children were examined using standa rdized tests of speech and language and perceptual measures of resonance an d voice. Results: Results show significant delay in emergence of speech and language milestones with delay/disorder in speech-language processes persi sting into the school aged years, including those children diagnosed with n onverbal learning disabilities. Persistent articulation and resonance disor ders were also present, presumed to be related in part to palatal anomalies . No correlation was found between cardiac status, learning disorders, pala te anomalies and communication disorders. Conclusion: The need for early id entification and management of communication skills is crucial in the care of children with the 22q11.2 deletion.