Subset analysis of RTOG 85-31 and 86-10 indicates an advantage for long-term vs. short-term adjuvant hormones for patients with locally advanced nonmetastatic prostate cancer treated with radiation therapy

Citation
Em. Horwitz et al., Subset analysis of RTOG 85-31 and 86-10 indicates an advantage for long-term vs. short-term adjuvant hormones for patients with locally advanced nonmetastatic prostate cancer treated with radiation therapy, INT J RAD O, 49(4), 2001, pp. 947-956
Citations number
21
Categorie Soggetti
Radiology ,Nuclear Medicine & Imaging","Onconogenesis & Cancer Research
Journal title
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
ISSN journal
03603016 → ACNP
Volume
49
Issue
4
Year of publication
2001
Pages
947 - 956
Database
ISI
SICI code
0360-3016(20010315)49:4<947:SAOR8A>2.0.ZU;2-7
Abstract
Purpose: The benefit of adjuvant hormones in prostate cancer patients recei ving definitive radiation therapy (RT)in RTOG 85-31 and 86-10 has previousl y been reported. This analysis excludes those patients with positive lymph nodes or postprostatectomy to determine the benefit of adjuvant hormones in men with locally advanced nonmetastatic prostate cancer receiving definiti ve RT, Methods and Materials: Nine hundred ninety-three eligible patients from RTO G 85-31 and 86-10 treated between 1987-1992 were included in this study. Fi ve hundred seventy-five patients with T3N0M0 disease were included from RTO G 85-31 and 418 patients with T2b-T4N0M0 disease from RTOG 86-10, Patients randomized to receive long-term hormones (LTH) on 85-31 received goserelin starting the last week of RT and continued indefinitely, Patients treated w ith short-term hormones (STH) on 86-10 received goserelin and flutamide 2 m onths prior to and during RT. The median follow-up for all patients in this analysis was 71 months (range, 0.6-129 months), Results: Combining both studies, statistically significant improvements in outcome were observed between the RT and hormones (I) and RT alone (II) gro ups for biochemical disease-free survival (bNED control) and distant metast ases failure (DMF), Statistically significant improvements in bNED control, DMF and cause-specific failure (CSF) were observed for patients receiving LTH compared with STH, In those patients receiving LTH, the benefit in bNED control (p = 0.0002), DMF (p = 0.05), and CSF (p = 0.02) was limited to ce ntrally reviewed Gleason score of 7 and 8-10 tumors, For all patients treat ed on 85-31, statistically significant improvements for bNED control, DMF, and CSF were observed between Group I and II. Multivariate analysis demonst rated Gleason score and the use of LTH to be independent predictors for bNE D control (p < 0.0001), DMF (p < 0.0001), and CSF (p < 0.002). Conclusions: Based on this analysis, adjuvant long-term hormones compared t o short-term hormones resulted in statistically significant improvements in bNED control, DMF, and CSF rates for patients with locally advanced nonmet astatic prostate cancer. (C) 2001 Elsevier Science Inc.