DNA vaccination for HIV-1 and SIV

Control of the worldwide AIDS epidemic will only be achieved with a safe an d effective prophylactic HIV-1 vaccine. DNA vaccination has recently emerge d as a promising vaccine modality that can elicit both humoral and cellular immune responses. HIV-1- and SIV-specific immune responses have been elici ted by DNA vaccines in both mice and nonhuman primates. However, these immu ne responses have not been capable of protecting nonhuman primates against pathogenic AIDS virus challenges. A number of approaches are therefore bein g investigated to augment DNA vaccine-elicited immune responses. Copyright (C) 2001 S. Karger AG, Basel.