Level of plasma tissue factor pathway inhibitor is inversely correlated with intraarterial diastolic pressure in subjects who underwent coronary angiography

There are only a few studies of the relationship between hemostatic abnorma lities and intraarterial pressure, so the present study investigated the as sociation of various newer lipid and hemostatic variables with intraarteria l pressure levels. Levels of total cholesterol, high-density lipoprotein ch olesterol (HDL-C), low-density lipoprotein cholesterol, triglyceride, lipop rotein-(a), remnant-like particle cholesterol, cholesteryl ester transfer p rotein, uric acid, blood glucose, fibrinogen, free form of tissue factor pa thway inhibitor (TFPI), C-reactive protein, serum amyloid A protein, anti-C hlamydia pneumoniae immunoglobulin G and immunoglobulin A, and apolipoprote ins (apo) A-I, B, and E were measured in 176 patients who underwent diagnos tic coronary angiography. Intraarterial blood pressure was determined from central aortic pressure using a standard fluid-filled catheter-external tra nsducer system. Multivariate regression analyses showed that TFPI level was the only independent factor associated with aortic diastolic pressure. The linear regression equation demonstrated a significant negative correlation of TFPI level with aortic diastolic pressure (r=-0.395, p=0.0011). With re spect to the association with other parameters, the TFPI level showed signi ficant correlations between the HDL-C level and the apo A-I level, both in the overall patients and in the patients with coronary artery stenosis. Thi s is the first evidence that the level of the plasma free form of TFPI is i nversely correlated to aortic diastolic pressure.