We report a case of synovitis in a 64-year-old man who developed the infect
ion while on steroid therapy for rheumatoid arthritis. Dolosigranulum pigru
m, a gram-positive catalase-negative coccus, was isolated from two sets of
blood cultures prior to antibiotic therapy. The patient was treated with 4
weeks of appropriate antibiotics, and the synovial inflammation resolved. A
lthough synovial aspirates were never positive for any bacteria or fungi, t
he timing of positive blood cultures and absence of other pathogens suggest
the possible etiology as D. pigrum.