Compartmentalized bone regeneration of cranial defects with biodegradable barriers: An animal model

In bony defects of the cranium, bone healing may be complicated by prolapse of surrounding tissue into the defect. This tissue acts as an impediment t o prevent the migration of osteogenic cells, leading to impaired bone forma tion. It has been previously shown that a membrane placed over the bony def ect inhibits the connective tissue cells from entering the wound and theore tically improves bone formation. The use of a proven resorbable material, L actosorb, is used in this animal model and has shown a significant increase in autogenous bony formation. The majority of previous work was accomplish ed with nonresorbable material that resulted in foreign body formation. Thi s paper is unique because resorbable material in the animal model is relati vely inexpensive and easy to use and has allowed successful autogenous bony regeneration.