Spontaneously infected cephalohematomas are rare occurrences; only five cas
es have been reported previously. Uninfected cephalohematomas are common an
d usually resolve without treatment. However, physicians should be aware th
at cephalohematomas are potential sites for infection and may require aspir
ation for diagnosis and treatment. Untreated infected cephalohematomas may
lead to osteomyelitis, epidural abscess, or subdural empyema. We present a
case of a spontaneously infected cephalohematoma with an associated osteomy
elitis which was successfully managed with drainage and long-term antibioti
cs. A review of the literature is also presented.