Control of the regioselectivity in catalytic transformations involving amphiphilic bis-allylpalladium intermediates: Mechanism and synthetic applications

Various dialkyl-substituted allyl chloride derivatives (2d-i) undergo regio selective palladium-catalyzed coupling reactions with allylstannanes (1a,b) and benzylidenemalonitrile (4), providing functionalized 1,7-octadienes in good yield. The catalytic reaction proceeds through an unsymmetrical amphi philic bis-allylpalladium intermediate. An:introductory electrophilic attac k on the terminal position of the unsubstituted alkyl moiety is followed by a nucleophilic attack on the alkyl-substituted allyl ligand. A theoretical analysis was performed by applying density functional theory at the B3PW91 /DZ+P level to study the substituent effects on the electrophilic attack. A ccording to the theoretical results, the high regioselectivity can be ascri bed to the electronic effects of the alkyl substituents: The terminal alkyl groups destabilize the eta (1),eta (3)-bis-allylpalladium intermediate of the reaction; in addition, the alkyl substitution increases the activation barrier for the electrophilic attack.