Neuroleptic malignant-like syndrome after abrupt withdrawal of baclofen

We present the case of a 36-year-old man who presented with a clinically ne uroleptic malignant-like syndrome involving disorientation, signs of autono mic dysfunction, rigidity and raised total creatine kinase level, but in th e absence of any neuroleptic medication. He had, however, abruptly stopped taking his longterm baclofen in the days prior to presentation. He improved markedly after the reintroduction of baclofen, and we postulate that his c linical syndrome resulted from the sudden withdrawal of this drug. We concu r with the concept that neuroleptic malignant syndrome represents a spectru m of disorders, and add it to the list of possible sequelae after abrupt wi thdrawal of baclofen.