Highly efficient enantioseparations in non-aqueous capillary electrochromatography using cellulose tris(3,5-dichlorophenylcarbamate) as chiral stationary phase

Enantioseparations of chiral compounds were studied by non-aqueous capillar y electrochromatography (NAQ CEC) with cellulose tris(3,5-dichlorophenylcar bamate) (CDCPC) coated on silica gel. The high chiral recognition ability o f CDCPC in polar organic solvents towards many analytes allowed the amount of the chiral selector loaded onto the surface of silica to be reduced sign ificantly. The reduced coating of the chiral selector allowed more effectiv e exploitation of the advantages of electrokinetically-driven flow compared to pressure-driven propulsion of the analyte. Plate numbers were obtained in the range of 180000-215000 m(-1) which are among the highest efficiencie s observed in chiral CEC.