Synthesis, characterization, and chromatographic evaluation of titanium tetrabutoxide-modified silica as a support for HPLC-RP separations in alkaline mobile phases

Authors
Silva, RB Gushikem, Y Collins, CH
Citation
Rb. Silva et al., Synthesis, characterization, and chromatographic evaluation of titanium tetrabutoxide-modified silica as a support for HPLC-RP separations in alkaline mobile phases, J SEP SCI, 24(1), 2001, pp. 49-54
Citations number
33
Categorie Soggetti
Spectroscopy /Instrumentation/Analytical Sciences
Journal title
JOURNAL OF SEPARATION SCIENCE
ISSN journal
16159314 → ACNP
Volume
24
Issue
1
Year of publication
2001
Pages
49 - 54
Database
ISI
SICI code
1615-9314(200101)24:1<49:SCACEO>2.0.ZU;2-W
Abstract
Gamma radiation was used to immobilize poly(methyloctylsiloxane) (PMOS) ont o the surface of silica particles titanized by reaction with titanium tetra butoxide. The irradiated particles were extracted with CH2Cl2 and subsequen tly packed into HPLC columns for testing. The PMOS- based stationary phases were tested chromatographically after each of a series of washings with pH 7 and pH 12 MeOH:NaOH(aq) 70:30 (v/v) mobile phases. Very slight decreases in column efficiency or retention time and no evidence of support dissolut ion were observed with either mobile phase.