TNF-alpha and IL-12: a balancing act in macrophage functioning

Authors
Ma, XJ
Citation
Xj. Ma, TNF-alpha and IL-12: a balancing act in macrophage functioning, MICROBES IN, 3(2), 2001, pp. 121-129
Citations number
66
Categorie Soggetti
Immunology
Journal title
MICROBES AND INFECTION
ISSN journal
12864579 → ACNP
Volume
3
Issue
2
Year of publication
2001
Pages
121 - 129
Database
ISI
SICI code
1286-4579(200102)3:2<121:TAIABA>2.0.ZU;2-V
Abstract
Tumor necrosis factor alpha (TNF-alpha) and interleukin 12 (IL-12) are two major macrophage-derived mediators of inflammatory responses in mammals. In creasing evidence suggests that TNF-alpha is a double-edged sword with both proinflammatory and anti-inflammatory propensities. This article discusses the inter-regulation of TNF-alpha and IL-12 and the impact on the function of macrophages in innate and adaptive immunity. (C) 2001 Editions scientif iques et medicales Elsevier SAS.