Increased expression of several mitochondrial genes in human and monkey B-cell non-Hodgkin lymphomas

Authors
Nikolaev, AI Martynenko, AV Kalmyrzaev, BB Inozemtseva, LI Dubovaya, VI Hunsmann, G Bodemer, B Tarantul, VZ
Citation
Ai. Nikolaev et al., Increased expression of several mitochondrial genes in human and monkey B-cell non-Hodgkin lymphomas, MOL BIOL, 35(1), 2001, pp. 108-114
Citations number
62
Categorie Soggetti
Molecular Biology & Genetics
Journal title
MOLECULAR BIOLOGY
ISSN journal
00268933 → ACNP
Volume
35
Issue
1
Year of publication
2001
Pages
108 - 114
Database
ISI
SICI code
0026-8933(200101/02)35:1<108:IEOSMG>2.0.ZU;2-T
Abstract
Mitochondrial genes overexpressed in human and monkey B-cell non-Hodgkin ly mphomas (B-NHLs) were sought via subtraction hybridization, cloning, and di fferential screening of the resulting cDNA libraries. The cDNAs of mitochon drial genes constituted an appreciable proportion of all lymphoma-specific cDNAs. Lymphomogenesis was associated with upregulation of a set of mitocho ndrial genes, which varied with lymphoma type but always included NADHIV. A possible association between upregulation of certain mitochondrial genes a nd cell malignant transformation is discussed.