Aldosterone synthase (CYP11B2) gene polymorphism and cerebral white matterhyperintensities

Authors
Verpillat, P Alperovitch, A Cambien, F Besancon, V Desal, H Tzourio, C
Citation
P. Verpillat et al., Aldosterone synthase (CYP11B2) gene polymorphism and cerebral white matterhyperintensities, NEUROLOGY, 56(5), 2001, pp. 673-675
Citations number
10
Categorie Soggetti
Neurology,"Neurosciences & Behavoir
Journal title
NEUROLOGY
ISSN journal
00283878 → ACNP
Volume
56
Issue
5
Year of publication
2001
Pages
673 - 675
Database
ISI
SICI code
0028-3878(20010313)56:5<673:AS(GPA>2.0.ZU;2-D
Abstract
The association between aldosterone synthase (CYP11B2) gene polymorphism an d white matter hyperintensities seen on cerebral MRI was studied in a popul ation-based sample of 829 individuals aged 63 to 75 years. The T allele was associated with the risk of severe white matter hyperintensities. Compared with the CC genotype, the adjusted OR for severe white matter hyperintensi ties was 4.61 (95% CI, 1.46 to 14.55) for the TT genotype and 2.45 (95% CI, 0.81 to 7.46) for the TC genotype in men. This association was independent of hypertension.