Functional coexpression of excitatory mGluR1 and mGluR5 on striatal cholinergic interneurons

Authors
Pisani, A Bonsi, P Centonze, D Bernardi, G Calabresi, P
Citation
A. Pisani et al., Functional coexpression of excitatory mGluR1 and mGluR5 on striatal cholinergic interneurons, NEUROPHARM, 40(3), 2001, pp. 460-463
Citations number
9
Categorie Soggetti
Neurosciences & Behavoir
Journal title
NEUROPHARMACOLOGY
ISSN journal
00283908 → ACNP
Volume
40
Issue
3
Year of publication
2001
Pages
460 - 463
Database
ISI
SICI code
0028-3908(200103)40:3<460:FCOEMA>2.0.ZU;2-F
Abstract
The group I mGluR agonist (S)- 3,5-dihydroxyphenylglycine (3,5-DHPG) and th e mGluR5 agonist 2-chloro-5-hydroxyphenylglycine both induced a membrane de polarisation of striatal cholinergic interneurons. The response to 3,5-DHPG was blocked only by the coadministration of mGluR1 and mGluR5 antagonists, suggesting that both mGluRs are involved in this excitatory effect in stri atal cholinergic interneurons. (C) 2001 Elsevier Science Ltd. All rights re served.