Whereas the cholesterol-lowering action of plant sterols and their derivati
ves has been well established, more recent results have produced new inform
ation concerning the similar effects of various mixtures and dose-response
relationships. Moreover, although these materials have generally been viewe
d as safe for long-term use in almost all sectors of the population, some c
oncerns remain regarding the impact of phytosterol consumption on other lip
id-soluble nutrients, which need to be further addressed. Further work: is
also required to define the relationship between plant sterol consumption,
circulating sterol levels, and risk of certain cancers.