BACKGROUND AND OBJECTIVE: GGRGDSPCA synthetic peptide competes for integrin
receptor in scar formation after glaucoma filtering surgery in a rabbit mo
del. The purpose of this study was to evaluate the use of this peptide and
compare it with mitomycin on glaucoma filtering surgery.
MATERIALS AND METHODS: Posterior sclerectomy was performed in both eyes of
17 rabbits. The right eye received GGRGDSPCA (p605) at 0, 4, 8, 12, and 1G
days after. Nine left eyes received saline as a control; the remaining 8 ey
es received mitomycin C at 0.5 mg/mL intraoperative. Intraocular pressures
and biomicroscopy were evaluated as well as bleb function.
RESULTS: Intraocular pressure decreased significantly in both the peptide a
nd mitomycin treated eyes in comparison with the saline group (P = 0.0003).
Pressure was similar in both groups. The blebs showed filtrating function
in a functional analysis at day 21 and 41 in the mitomycin cases as well as
in the peptide group. Histologic analysis performed in both peptide and mi
tomycin groups showed inhibitory effect in fibrocellular and collagen organ
ization with bleb formation.
CONCLUSIONS: The p605 peptide showed to be similar to mitomycin C in contro
lling and improving glaucoma filtering surgery in rabbits. This alternative
may potentially be useful for similar purposes in humans for the control o
f glaucoma and improvement of filtering surgery.