Synthesis and stereochemical elucidation of a 14-membered ring phosphonate

Authors
Pungente, MD Weiler, L
Citation
Md. Pungente et L. Weiler, Synthesis and stereochemical elucidation of a 14-membered ring phosphonate, ORG LETT, 3(5), 2001, pp. 643-646
Citations number
11
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
ORGANIC LETTERS
ISSN journal
15237060 → ACNP
Volume
3
Issue
5
Year of publication
2001
Pages
643 - 646
Database
ISI
SICI code
1523-7060(20010308)3:5<643:SASEOA>2.0.ZU;2-U
Abstract
[GRAPHICS] We report the synthesis and stereochemical elucidation of a 14-membered rin g phosphonate, The key step in the synthesis of the macrolide phosphonate w as the cyclization of the acyclic precursor using the Mitsunobu reaction, a mild reaction for the preparation of mixed phosphonates.