Approach to the synthesis of antitumor quassinoids from labdane diterpenes: An efficient synthesis of a picrasane-related intermediate

Authors
Barrero, AF Alvarez-Manzaneda, EJ Alvarez-Manzaneda, R Chahboun, R Meneses, R Cuerva, JM Aparicio, M Romera, JL
Citation
Af. Barrero et al., Approach to the synthesis of antitumor quassinoids from labdane diterpenes: An efficient synthesis of a picrasane-related intermediate, ORG LETT, 3(5), 2001, pp. 647-650
Citations number
36
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
ORGANIC LETTERS
ISSN journal
15237060 → ACNP
Volume
3
Issue
5
Year of publication
2001
Pages
647 - 650
Database
ISI
SICI code
1523-7060(20010308)3:5<647:ATTSOA>2.0.ZU;2-I
Abstract
[GRAPHICS] The tetracyclic ketal 24, a suitable intermediate for the synthesis of anti tumor pentacyclic quassinoids, has been efficiently prepared from communic acids (5a-c), via methyl ketone 9, The synthetic sequence from 9 to 24 cons ists of 15 steps in 12% overall yield.